The traceless Staudinger ligation for indirect 18F-radiolabelling

Org Biomol Chem. 2011 Jan 7;9(1):136-40. doi: 10.1039/c0ob00564a. Epub 2010 Nov 22.

Abstract

The Staudinger ligation of phosphine-substituted thioesters with (18)F-fluoroethylazide has been successfully applied to access (18)F-labelled molecules in radiochemical yields superior to 95%; the first fluorous variant of a Staudinger radio-ligation has been validated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Esters / chemistry*
  • Fluorine Radioisotopes / chemistry
  • Molecular Structure
  • Phosphines / chemistry*
  • Sulfhydryl Compounds / chemistry*

Substances

  • Esters
  • Fluorine Radioisotopes
  • Phosphines
  • Sulfhydryl Compounds
  • phosphine