Thermo-responsive polymer brushes as intelligent biointerfaces: preparation via ATRP and characterization

Macromol Biosci. 2011 Mar 10;11(3):400-9. doi: 10.1002/mabi.201000312. Epub 2010 Nov 19.


PIPAAm-brush grafted glass substrates with various graft densities and chain lengths were prepared via surface-initiated ATRP. Temperature-dependent physicochemical properties of the surfaces were characterized by means of ATR/FT-IR spectroscopy, XPS, AFM, and contact angle measurements. ATRP conditions influence the amount of grafted PIPAAm and the surface wettability and roughness of the substrate. Fibronectin adsorption and EC adhesion increased with decreasing density of PIPAAm brushes. EC adhesion was diminished with increasing PIPAAm graft length. Thus, the preparation of PIPAAm brush surface with various graft densities and chain lengths using the surface-initiated ATRP is an effective method for modulating thermo-responsive properties of surfaces.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylic Resins / chemical synthesis*
  • Acrylic Resins / chemistry
  • Acrylic Resins / pharmacology
  • Adsorption / drug effects
  • Animals
  • Biocompatible Materials / chemical synthesis*
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / pharmacology
  • Carotid Arteries / cytology
  • Cattle
  • Cell Adhesion / drug effects
  • Cell Shape / drug effects
  • Endothelial Cells / cytology
  • Endothelial Cells / drug effects
  • Fibronectins / pharmacology
  • Glass
  • Materials Testing / methods*
  • Microscopy, Atomic Force
  • Photoelectron Spectroscopy
  • Polymerization* / drug effects
  • Surface Properties / drug effects
  • Temperature*


  • Acrylic Resins
  • Biocompatible Materials
  • Fibronectins
  • poly-N-isopropylacrylamide