Latent celiac disease in reproductive performance of women

Fertil Steril. 2011 Mar 1;95(3):922-7. doi: 10.1016/j.fertnstert.2010.11.005. Epub 2010 Nov 24.


Objective: To investigate the prevalence of positive serologic findings for celiac disease in Indian women with poor reproductive performance.

Design: Cross-sectional except that the women with intrauterine growth restriction were followed prospectively until delivery.

Setting: Department of Obstetrics and Gynecology of a tertiary teaching hospital, New Delhi.

Patient(s): Eight hundred ninety-three women (104 women with idiopathic recurrent abortion, 104 women with unexplained stillbirth, 230 cases of unexplained infertility, 150 pregnant women with idiopathic intrauterine growth restriction, 305 control cases).

Intervention(s): None.

Main outcome measure(s): The presence of antigliadin IgA and IgG, anti-tissue transglutaminase IgA by ELISA, and IgA antiendomysium antibody by indirect immunofluorescence microscopy.

Result(s): The seroprevalence of transglutaminase IgA was 6.70% in the group with recurrent abortion, 5.70% in the group with stillbirth, 5.65% in the group with infertility, 9.33% in the group with intrauterine growth restriction, and 1.30% in the control group. Rates of previous preterm births, low-birth-weight infants, and cesarean section were higher in seropositive women compared with seronegative subjects.

Conclusion(s): Women having poor reproductive performance had subclinical celiac disease. The serology for celiac disease can be considered in idiopathic cases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abortion, Habitual / epidemiology*
  • Abortion, Habitual / immunology
  • Adult
  • Asymptomatic Diseases / epidemiology*
  • Autoantibodies / blood*
  • Celiac Disease / epidemiology*
  • Celiac Disease / immunology
  • Cesarean Section / statistics & numerical data
  • Cross-Sectional Studies
  • Female
  • Humans
  • Immunoglobulin A / blood
  • Immunoglobulin G / blood
  • India / epidemiology
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Pregnancy
  • Premature Birth / epidemiology*
  • Premature Birth / immunology
  • Prevalence
  • Seroepidemiologic Studies
  • Transglutaminases / immunology
  • Young Adult


  • Autoantibodies
  • Immunoglobulin A
  • Immunoglobulin G
  • Transglutaminases