Synthetic double-stranded RNA stimulates the expression of interferon-inducible protein 10 in human mesothelial cells

Clin Vaccine Immunol. 2011 Jan;18(1):176-9. doi: 10.1128/CVI.00007-10. Epub 2010 Nov 24.

Abstract

Interferon-inducible protein 10 (IP-10) is a chemokine playing an important role in the restriction of viral spread. A time- and dose-dependent increase in IP-10 is found upon activation of viral receptors expressed on mesothelial cells, which provides novel evidence for a link between viral infections and inflammation of serous membranes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chemokine CXCL10 / metabolism*
  • Epithelial Cells / immunology
  • Epithelial Cells / metabolism*
  • Epithelial Cells / virology
  • Epithelium / immunology
  • Epithelium / metabolism
  • Epithelium / virology
  • Humans
  • RNA, Double-Stranded / chemical synthesis
  • RNA, Double-Stranded / immunology*
  • Receptors, Virus / metabolism
  • Up-Regulation
  • Virus Diseases / immunology*
  • Viruses / immunology

Substances

  • Chemokine CXCL10
  • RNA, Double-Stranded
  • Receptors, Virus