Dictyostelium discoideum is a haploid social soil amoeba that is an established host model for several human pathogens. The research areas presently pursued include the use of D. discoideum to identify genetic host factors determining the outcome of infections and the use as screening system for identifying bacterial virulence factors. Here we report about the Legionella pneumophila directed phagosome biogenesis and the cell-to-cell spread of Mycobacterium species. Moreover, we highlight recent insights from the host-pathogen cross-talk between D. discoideum and the pathogens Salmonella typhimurium, Klebsiella pneumoniae, Yersinia pseudotuberculosis, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Burkholderia cenocepacia, Vibrio cholerae and Neisseria meningitidis.
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