WNT1 inducible signaling pathway protein 1 (WISP1): a novel mediator linking development and disease

Barbara Berschneider; Melanie Königshoff

doi:10.1016/j.biocel.2010.11.013

WNT1 inducible signaling pathway protein 1 (WISP1): a novel mediator linking development and disease

Int J Biochem Cell Biol. 2011 Mar;43(3):306-9. doi: 10.1016/j.biocel.2010.11.013. Epub 2010 Nov 23.

Authors

Barbara Berschneider¹, Melanie Königshoff

Affiliation

¹ Comprehensive Pneumology Center, Ludwig-Maximilians-University, University Hospital Grosshadern, Max-Lebsche-Platz 31, 81377 Munich, Germany.

PMID: 21109017
DOI: 10.1016/j.biocel.2010.11.013

Abstract

WISP1 is a secreted, matricellular protein allocated to the CCN protein family. The CCN protein family consists of six, modular structured, secreted proteins. WISP1 is mainly expressed during organ development and under diseased conditions, such as fibrosis or cancer. Its expression is associated with proliferation, cytoprotection, as well as extracellular matrix production, thereby representing a highly attractive therapeutical target for future applications.

Publication types

Review

MeSH terms

Animals
Disease*
Embryonic Development*
Humans
Models, Biological
Proto-Oncogene Proteins / chemistry
Proto-Oncogene Proteins / metabolism*
Signal Transduction

Substances

Proto-Oncogene Proteins