Metabolic regulation of stem cell behavior and implications for aging

Cell Metab. 2010 Dec 1;12(6):561-5. doi: 10.1016/j.cmet.2010.11.010.


Caloric intake influences metabolic homeostasis, somatic maintenance, tissue regeneration, and longevity in metazoans. Recent studies indicate that nutrient-dependent changes in stem cell populations play an important role in these effects. Here, we review the emerging picture of how nutrient-sensing pathways affect stem cell behavior, providing a mechanism to influence life span.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Germ Cells / cytology*
  • Humans
  • Longevity / physiology*
  • Metabolic Networks and Pathways / physiology*
  • Nutritional Status / physiology*
  • Signal Transduction / physiology*
  • Stem Cells / cytology*