Neuroscience. Lynx for braking plasticity

Science. 2010 Nov 26;330(6008):1189-90. doi: 10.1126/science.1198983.

Abstract

Knocking out the Lynx1 gene restores plasticity in the visual cortex of adult mice.

Publication types

  • Comment
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging
  • Amblyopia / physiopathology
  • Amblyopia / therapy
  • Animals
  • Chondroitin Sulfate Proteoglycans / physiology
  • Dominance, Ocular*
  • Membrane Glycoproteins / genetics*
  • Membrane Glycoproteins / physiology*
  • Mice
  • Mice, Knockout
  • Neuronal Plasticity*
  • Neuropeptides / genetics*
  • Neuropeptides / physiology*
  • Nicotinic Antagonists
  • Receptors, Immunologic / physiology
  • Receptors, Nicotinic / metabolism
  • Sensory Deprivation
  • Signal Transduction
  • Vision, Ocular*
  • Visual Cortex / physiology*
  • Visual Pathways / physiology

Substances

  • Chondroitin Sulfate Proteoglycans
  • Lynx1 protein, mouse
  • Membrane Glycoproteins
  • Neuropeptides
  • Nicotinic Antagonists
  • Pirb protein, mouse
  • Receptors, Immunologic
  • Receptors, Nicotinic