SF-1 in the ventral medial hypothalamic nucleus: a key regulator of homeostasis

Mol Cell Endocrinol. 2011 Apr 10;336(1-2):219-23. doi: 10.1016/j.mce.2010.11.019. Epub 2010 Nov 24.


The ventral medial hypothalamic nucleus (VMH) regulates food intake and body weight homeostasis. The nuclear receptor NR5A1 (steroidogenic factor 1; SF-1) is a transcription factor whose expression is highly restricted in the VMH and is required for the development of the nucleus. Neurons expressing SF-1 in the VMH have emerged as playing important roles in the regulation of body weight and energy homeostasis. Many of these studies have used site-specific gene KO approaches, providing insights into the molecular mechanisms underlying the regulation of energy homeostasis by the SF-1 neurons of the VMH. In this brief review, we will focus on recent studies defining the molecular mechanisms regulating energy homeostasis and body weight in the VMH, particularly stressing the SF-1 expressing neurons.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Homeostasis*
  • Humans
  • Integrases / metabolism
  • Leptin / metabolism
  • Neurons / metabolism
  • Steroidogenic Factor 1 / metabolism*
  • Ventromedial Hypothalamic Nucleus / metabolism*


  • Leptin
  • Steroidogenic Factor 1
  • Cre recombinase
  • Integrases