What determines the specificity and outcomes of ubiquitin signaling?

Cell. 2010 Nov 24;143(5):677-81. doi: 10.1016/j.cell.2010.10.026.


Ubiquitin signals and ubiquitin-binding domains are implicated in almost every cellular process, but how is their functionality achieved in cells? We assess recent advances in monitoring the dynamics and specificity of ubiquitin networks in vivo and discuss challenges ahead.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Humans
  • Protein Interaction Domains and Motifs
  • Proteins / chemistry
  • Proteins / metabolism
  • Signal Transduction*
  • Ubiquitin / chemistry
  • Ubiquitin / metabolism*
  • Ubiquitination


  • Proteins
  • Ubiquitin