Regulation of Drosophila lifespan by JNK signaling

Exp Gerontol. 2011 May;46(5):349-54. doi: 10.1016/j.exger.2010.11.003. Epub 2010 Nov 25.


Cellular responses to extrinsic and intrinsic insults have to be carefully regulated to properly coordinate cytoprotection, repair processes, cell proliferation and apoptosis. Stress signaling pathways, most prominently the Jun-N-terminal Kinase (JNK) pathway, are critical regulators of such cellular responses and have accordingly been implicated in the regulation of lifespan in various organisms. JNK signaling promotes cytoprotective gene expression, but also interacts with the insulin signaling pathway to influence growth, metabolism, stress tolerance and regeneration. Here, we review recent studies in Drosophila that elucidate the tissue-specific and systemic consequences of JNK activation that ultimately impact lifespan of the organism.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Aging / physiology*
  • Animals
  • Drosophila melanogaster / physiology*
  • JNK Mitogen-Activated Protein Kinases / physiology*
  • Longevity / physiology*
  • Models, Animal
  • Signal Transduction / physiology*


  • JNK Mitogen-Activated Protein Kinases