Prevalence of Diabetes in Patients With Bipolar Disorder in Taiwan: A Population-Based National Health Insurance Study

Gen Hosp Psychiatry. Nov-Dec 2010;32(6):577-82. doi: 10.1016/j.genhosppsych.2010.09.005. Epub 2010 Oct 23.


Objective: We investigated the prevalence and correlates of diabetes in patients with bipolar disorder in Taiwan.

Methods: The National Health Research Institute provided a database of 1,000,000 random subjects from which we selected a sample of 766,427 subjects aged 18 years and over. We identified study subjects who had at least one service claim during 2005, with a primary diagnosis of bipolar disorder or with a prescription for treatment of diabetes.

Results: The prevalence of diabetes in patients with bipolar disorder was higher than in the general population (10.77% vs. 5.57%, OR, 2.01; 99% CI, 1.64-2.48). Compared with the general population, patients with bipolar disorder had a higher prevalence of diabetes in all age groups under 60 years; among females and males; among lower insurance amount groups; among those living in the northern, central and southern regions and among residents living in urban and rural areas. Antipsychotic use was associated with a higher prevalence of diabetes in persons with bipolar disorder.

Conclusions: Patients with bipolar disorder had a higher prevalence of diabetes than the general population. Prevention, early detection and treatment of diabetes are important issues for patients with bipolar disorder.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antipsychotic Agents / adverse effects*
  • Antipsychotic Agents / therapeutic use*
  • Bipolar Disorder / drug therapy*
  • Bipolar Disorder / epidemiology*
  • Comorbidity
  • Cross-Cultural Comparison*
  • Cross-Sectional Studies
  • Diabetes Mellitus / chemically induced*
  • Diabetes Mellitus / epidemiology*
  • Female
  • Health Surveys
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • National Health Programs / statistics & numerical data
  • Risk Factors
  • Statistics as Topic
  • Taiwan
  • Young Adult


  • Antipsychotic Agents