Liposome-encapsulated ropivacaine for intraoral topical anesthesia

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Dec;110(6):800-4. doi: 10.1016/j.tripleo.2010.07.005.

Abstract

Objectives: This study evaluated the efficacy of liposome-encapsulated 2% ropivacaine in topical anesthesia and its influence on pulpal response.

Study design: Forty volunteers received the following topical formulations in the buccal fold of the maxillary lateral incisors region (bilaterally): liposome-encapsulated 2% ropivacaine gel (RL2); 20% benzocaine gel (B20); liposomal placebo gel (LP); and placebo gel (P). Formulations were kept in place for 30 minutes, during which time the teeth were electric pulp tested every 10 minutes. After this procedure, a dental needle was inserted until periosteum contact in the same site of topical application and pain was rated by a visual analog scale. Duration of soft tissue anesthesia was assessed by pinprick test.

Results: RL2 and B20 showed lower pain response to needle insertion and longer soft tissue anesthesia then P and LP (P = .0003 and P < .0001, respectively); however, RL2 was not different from B20 (P > .05) regarding those parameters. None of the formulations was able to induce pulpal anesthesia.

Conclusion: RL2 was as effective as B20 in reducing pain during needle insertion and inducing soft tissue anesthesia; however, neither one was able to induce pulpal anesthesia after a 30-min application.

Trial registration: ClinicalTrials.gov NCT01054547.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Amides / administration & dosage*
  • Amides / chemistry
  • Anesthesia, Dental*
  • Anesthetics, Local / administration & dosage*
  • Anesthetics, Local / chemistry
  • Benzocaine / administration & dosage
  • Benzocaine / chemistry
  • Chemistry, Pharmaceutical
  • Cross-Over Studies
  • Dental Pulp / drug effects
  • Dental Pulp Test
  • Double-Blind Method
  • Female
  • Gels
  • Humans
  • Incisor / drug effects
  • Liposomes
  • Male
  • Mouth Mucosa / drug effects
  • Needles
  • Pain Measurement
  • Placebos
  • Ropivacaine
  • Sensation / drug effects
  • Time Factors
  • Young Adult

Substances

  • Amides
  • Anesthetics, Local
  • Gels
  • Liposomes
  • Placebos
  • Ropivacaine
  • Benzocaine

Associated data

  • ClinicalTrials.gov/NCT01054547