Elevated fructosamine concentrations caused by IgA paraproteinemia in two dogs

J Vet Sci. 2010 Dec;11(4):359-61. doi: 10.4142/jvs.2010.11.4.359.


An 8-year-old male Austrian Pinscher and a 14-year-old male Golden Retriever were presented for evaluation due to unexplainable high fructosamine values despite euglycemia and epistaxis in combination with polydipsia/polyuria, respectively. Blood analysis revealed severe hyperglobulinemia, hypoalbuminemia and markedly elevated fructosamine concentrations in both dogs. Multiple myeloma with IgA-monoclonal gammopathy was diagnosed by serum and urine electrophoresis including immunodetection with an anti-dog IgA antibody and bone marrow aspirations. Diabetes mellitus was excluded by repeated plasma and urine glucose measurements. Fructosamine values were positively correlated with globulin, but negatively correlated with albumin concentrations. These cases suggest that, as in human patients, monoclonal IgA gammopathy should be considered as a possible differential diagnosis for dogs with high fructosamine concentrations.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Blood Proteins / analysis
  • Dog Diseases / blood*
  • Dog Diseases / drug therapy
  • Dogs
  • Fructosamine / blood*
  • Immunoglobulin A / metabolism*
  • Male
  • Melphalan / therapeutic use
  • Multiple Myeloma / complications
  • Multiple Myeloma / drug therapy
  • Multiple Myeloma / veterinary*
  • Myeloablative Agonists / therapeutic use
  • Paraproteinemias / blood
  • Paraproteinemias / complications
  • Paraproteinemias / drug therapy
  • Paraproteinemias / veterinary*


  • Blood Proteins
  • Immunoglobulin A
  • Myeloablative Agonists
  • Fructosamine
  • Melphalan