Prospective randomized controlled study on bestatin in resectable gastric cancer--third report

Jpn J Surg. 1990 Mar;20(2):186-91. doi: 10.1007/BF02470767.


The efficacy of Bestatin as adjuvant immunochemotherapy for patients with resectable gastric cancer was investigated. Ninety-six patients with similar background factors were randomized into two groups; a control group and an experimental group, the patients in the experimental group receiving a daily oral dose of 60 mg Bestatin over a long period. All 96 patients were treated with a bolus intravenous injection of mitomycin C (MMC) plus oral administration of tegafur (FT-207, FT). The survival rate of the patients in the MMC + FT + Bestatin group was more favorable than that of the patients in the MMC + FT group, but the difference was not statistically significant. The survival rates of the MMC + FT + Bestatin group patients in the stratification of stage III + IV and positive histological serosal invasion, ps(+), were significantly superior to those of the MMC + FT group patients (Logrank test: p less than 0.05). Moreover, in patients with positive histological serosal invasion, the recurrence of peritoneal dissemination was significantly suppressed in the MMC + FT + Bestatin group.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adjuvants, Immunologic / administration & dosage*
  • Aminopeptidases / antagonists & inhibitors*
  • Antibiotics, Antineoplastic / administration & dosage*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Gastrectomy
  • Humans
  • Leucine / administration & dosage
  • Leucine / analogs & derivatives*
  • Lymphocyte Activation
  • Mitomycin
  • Mitomycins / administration & dosage
  • Neoplasm Invasiveness
  • Neoplasm Recurrence, Local
  • Prospective Studies
  • Randomized Controlled Trials as Topic
  • Stomach Neoplasms / drug therapy
  • Stomach Neoplasms / mortality
  • Stomach Neoplasms / surgery*
  • Survival Rate
  • Tegafur / administration & dosage
  • Tuberculin Test


  • Adjuvants, Immunologic
  • Antibiotics, Antineoplastic
  • Mitomycins
  • Tegafur
  • Mitomycin
  • Aminopeptidases
  • Leucine
  • ubenimex