Before you analyze a human specimen, think quality, variability, and bias

Anal Chem. 2011 Jan 1;83(1):8-13. doi: 10.1021/ac1018974. Epub 2010 Nov 29.


Personalized medicine requires capabilities to detect and measure health-associated biomarkers with increasingly specific and sensitive methods, putting analytical chemists at the front lines of translational research. Analytical scientists must be upstream in the experimental design process because the analysis of a biospecimen (tissue, blood, etc.) presents technical and experimental design complexities. (To listen to a podcast about this feature, please go to the Analytical Chemistry multimedia page at

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Artifacts*
  • Blood Chemical Analysis
  • Chemistry Techniques, Analytical
  • Clinical Chemistry Tests / methods*
  • Clinical Chemistry Tests / standards
  • Humans
  • Precision Medicine
  • Reference Standards