Abstract
Lantipeptides are ribosomally synthesized and posttranslationally modified peptides containing thioether cross-links. We describe the preparation of seven different lantipeptides in Escherichia coli and demonstrate that this methodology can be used to incorporate nonproteinogenic amino acids.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids / chemistry
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Escherichia coli / metabolism*
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Peptides / chemistry
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Peptides / metabolism*
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Protein Conformation
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Protein Processing, Post-Translational*
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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Sulfhydryl Compounds / chemistry
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Sulfhydryl Compounds / metabolism
Substances
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Amino Acids
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Peptides
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Sulfhydryl Compounds