Current concepts regarding the HTLV-1 receptor complex

Retrovirology. 2010 Nov 29;7:99. doi: 10.1186/1742-4690-7-99.

Abstract

The identity of the Human T lymphotropic Virus type 1 (HTLV-1) receptor remained an unsolved puzzle for two decades, until the recent demonstration that three molecules, Glucose Transporter 1, Neuropilin-1 and Heparan Sulfate Proteoglycans are involved in HTLV-1 binding and entry. Despite these advances, several questions remain unanswered, including the precise role of each of these molecules during virus entry. In light of the most recent data, we propose a model of the HTLV-1 receptor complex and discuss its potential impact on HTLV-1 infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Glucose Transporter Type 1 / physiology
  • HTLV-I Infections / virology*
  • Heparan Sulfate Proteoglycans / physiology
  • Human T-lymphotropic virus 1 / pathogenicity
  • Human T-lymphotropic virus 1 / physiology*
  • Humans
  • Neuropilin-1 / physiology
  • Receptors, Virus / metabolism*
  • Virus Attachment

Substances

  • Glucose Transporter Type 1
  • Heparan Sulfate Proteoglycans
  • Receptors, Virus
  • Neuropilin-1