Antiobesity effects of green tea catechins: a mechanistic review

J Nutr Biochem. 2011 Jan;22(1):1-7. doi: 10.1016/j.jnutbio.2010.06.006. Epub 2010 Nov 5.


Green tea catechins (GTC) are polyphenolic compounds present in the unfermented dried leaves of the plant, Camellia sinensis. Results from a number of randomized, controlled intervention trials have shown that consumption of GTC (270 mg to 1200 mg/day) may reduce body weight and fat. There are several proposed mechanisms whereby GTC may influence body weight and composition. The predominating hypothesis is that GTC influences sympathetic nervous system (SNS) activity, increasing energy expenditure and promoting the oxidation of fat. Caffeine, naturally present in green tea, also influences SNS activity, and may act synergistically with GTC to increase energy expenditure and fat oxidation. Other potential mechanisms include modifications in appetite, up-regulation of enzymes involved in hepatic fat oxidation, and decreased nutrient absorption. This article reviews the evidence for each of these purported mechanisms, with particular reference to studies in humans.

Publication types

  • Review

MeSH terms

  • Adiposity / drug effects
  • Animals
  • Anti-Obesity Agents / pharmacology*
  • Anti-Obesity Agents / therapeutic use*
  • Appetite Depressants / pharmacology
  • Appetite Depressants / therapeutic use
  • Caffeine / pharmacology
  • Caffeine / therapeutic use
  • Catechin / pharmacology*
  • Catechin / therapeutic use*
  • Drug Synergism
  • Drug Therapy, Combination
  • Energy Metabolism / drug effects
  • Humans
  • Intestinal Absorption / drug effects
  • Lipid Metabolism / drug effects
  • Obesity / drug therapy*
  • Obesity / metabolism*
  • Tea / chemistry*
  • Weight Loss / drug effects


  • Anti-Obesity Agents
  • Appetite Depressants
  • Tea
  • Caffeine
  • Catechin