The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing

Philos Trans R Soc Lond B Biol Sci. 2011 Jan 12;366(1561):9-16. doi: 10.1098/rstb.2010.0276.


Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in species throughout the animal kingdom. This life-extension pathway, the first to be defined, was discovered through genetic studies in the small roundworm Caenorhabditis elegans. This discovery is described here.

Publication types

  • Review

MeSH terms

  • Aging / genetics
  • Aging / physiology*
  • Animals
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans / physiology*
  • Insulin / genetics
  • Insulin / physiology*
  • Insulin-Like Growth Factor I / genetics
  • Insulin-Like Growth Factor I / physiology*
  • Mutation*
  • Signal Transduction


  • Insulin
  • Insulin-Like Growth Factor I