Abstract
Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in species throughout the animal kingdom. This life-extension pathway, the first to be defined, was discovered through genetic studies in the small roundworm Caenorhabditis elegans. This discovery is described here.
MeSH terms
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Aging / genetics
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Aging / physiology*
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Animals
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Caenorhabditis elegans / genetics
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Caenorhabditis elegans / physiology*
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Insulin / genetics
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Insulin / physiology*
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Insulin-Like Growth Factor I / genetics
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Insulin-Like Growth Factor I / physiology*
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Mutation*
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Signal Transduction
Substances
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Insulin
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Insulin-Like Growth Factor I