The Potential Cardioprotective Effects of Hydrogen in Irradiated Mice

J Radiat Res. 2010;51(6):741-7. doi: 10.1269/jrr.10093.

Abstract

Most ionizing radiation-induced damage is caused by hydroxyl radicals, and the selective reduction of hydroxyl by hydrogen in vitro has been demonstrated previously. Irradiation of the heart can cause chronic cardiac disease. This study was designed to test the hypothesis that hydrogen-rich water (pure water saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ionizing irradiation injury in mice. In this paper, we demonstrate that hydrogen can protect myocardium degeneration from radiation-induced injury, decrease myocardium malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG) levels, and increase myocardium endogenous antioxidants in vivo. We suggest that hydrogen has a cardioprotective effect against radiation induced injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 8-Hydroxy-2'-Deoxyguanosine
  • Animals
  • Antioxidants / metabolism
  • Cardiotonic Agents / pharmacology*
  • Deoxyguanosine / analogs & derivatives
  • Deoxyguanosine / metabolism
  • Heart / drug effects*
  • Heart / radiation effects*
  • Heart Injuries / metabolism
  • Heart Injuries / prevention & control
  • Hydrogen / pharmacology*
  • Male
  • Malondialdehyde / metabolism
  • Mice
  • Mice, Inbred BALB C
  • Myocardium / metabolism
  • Myocardium / pathology
  • Radiation Injuries, Experimental / metabolism
  • Radiation Injuries, Experimental / prevention & control

Substances

  • Antioxidants
  • Cardiotonic Agents
  • Malondialdehyde
  • Hydrogen
  • 8-Hydroxy-2'-Deoxyguanosine
  • Deoxyguanosine