Charting histone modifications and the functional organization of mammalian genomes

Nat Rev Genet. 2011 Jan;12(1):7-18. doi: 10.1038/nrg2905. Epub 2010 Nov 30.


A succession of technological advances over the past decade have enabled researchers to chart maps of histone modifications and related chromatin structures with increasing accuracy, comprehensiveness and throughput. The resulting data sets highlight the interplay between chromatin and genome function, dynamic variations in chromatin structure across cellular conditions, and emerging roles for large-scale domains and higher-ordered chromatin organization. Here we review a selection of recent studies that have probed histone modifications and successive layers of chromatin structure in mammalian genomes, the patterns that have been identified and future directions for research.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Chromatin / metabolism*
  • Chromatin / ultrastructure
  • Genome*
  • Histones / genetics*
  • Histones / metabolism*
  • Humans
  • Mice
  • Protein Processing, Post-Translational / genetics
  • Regulatory Sequences, Nucleic Acid


  • Chromatin
  • Histones