Abstract
The intra-plantar injection of carrageenan elicited an inflammatory response characterized by increase of the paw thickness and infiltration of neutrophils in paw tissues. Histidine, n-acetylcysteine and diclofenac decreased paw thickness, and neutrophil infiltration in the paw tissues. The anti-inflammatory effect induced by co-administration of histidine and n-acetylcysteine with diclofenac, was more than that obtained from histidine and n-acetylcysteine administered alone. The results suggested that histidine, n-acetylcysteine and diclofenac produced anti-inflammatory activities by reducing paw edema and neutrophil infiltrationin induced by carrageenan. Inhibition of cyclooxygenase products such as prostaglandins may be involved in the anti-inflammatory effects induced by histidine and n-acetylcysteine.
MeSH terms
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Acetylcysteine / administration & dosage
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Acetylcysteine / pharmacology*
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Acute Disease
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Animals
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Carrageenan
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Cyclooxygenase Inhibitors / administration & dosage
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Cyclooxygenase Inhibitors / pharmacology
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Diclofenac / administration & dosage
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Diclofenac / pharmacology*
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Drug Synergism
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Edema / chemically induced
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Edema / immunology
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Edema / prevention & control
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Free Radical Scavengers / administration & dosage
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Free Radical Scavengers / pharmacology
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Hindlimb / drug effects
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Hindlimb / immunology
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Hindlimb / pathology
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Histidine / administration & dosage
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Histidine / pharmacology*
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Inflammation / chemically induced
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Inflammation / immunology
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Inflammation / prevention & control*
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Injections / methods
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Male
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Neutrophil Infiltration / drug effects
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Rats
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Rats, Wistar
Substances
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Cyclooxygenase Inhibitors
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Free Radical Scavengers
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Diclofenac
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Histidine
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Carrageenan
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Acetylcysteine