Evolution of the mitochondrial genetic code. IV. AAA as an asparagine codon in some animal mitochondria

J Mol Evol. 1990 Apr;30(4):329-32. doi: 10.1007/BF02101887.


Differences in assignments from those in the universal genetic code occur in codes of mitochondria. In this report, the published sequences of the mitochondrial genes for COI and ND1 in a platyhelminth (Fasciola hepatica) are examined and it is concluded that AAA may be a codon for asparagine instead of lysine, whereas AAG is the sole codon for lysine in this species.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Asparagine / genetics*
  • Bacteria / genetics
  • Base Sequence
  • Biological Evolution*
  • Codon / genetics*
  • Echinodermata / genetics
  • Fasciola hepatica / genetics*
  • Genetic Code
  • Humans
  • Insecta / genetics
  • Mammals / genetics
  • Mitochondria*
  • Molecular Sequence Data
  • RNA, Messenger / genetics*
  • RNA, Transfer, Lys / genetics


  • Codon
  • RNA, Messenger
  • RNA, Transfer, Lys
  • Asparagine