Alcohol-use disorders and depression: results from individual patient data meta-analysis of the acamprosate-controlled studies

Alcohol Alcohol. 2011 Jan-Feb;46(1):61-7. doi: 10.1093/alcalc/agq077. Epub 2010 Nov 30.


Aims: To examine the predictors and correlates of depression in alcoholic patients following detoxification and during outpatient treatment, and the role of acamprosate.

Method: The international research program of acamprosate has involved 6500 patients in randomized, placebo-controlled trials. Extensive baseline and follow-up data were documented for each patient. An individual patient data meta-analysis was conducted on a partial database.

Results: From 3354 patients in 11 studies (10 countries), we found 1120 (33.4% confidence intervals: 31.8-35.0) depressed patients (DPs). Among alcohol patients, the profile of DPs can be defined by five predictors: being female, younger, unemployed and living alone and being an episodic drinker. Compared with non-depressed patients (NDPs), their motivation to start a treatment and the compliance to treatment were lower. DPs performed less than NDPs in achieving abstinence. The acamprosate effect in increasing abstinence was similar for both DPs and NDPs patients. Abstinence during the trial was the key factor of depression remission: DPs were 7.58 times more likely to become NDPs if they were continuously abstinent.

Conclusion: Our results justify the need to systematically identify depression among alcohol-dependent patients, but to treat the alcohol dependence as a first step, because enhancing abstinence will often involve remission of the depressive disorder.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acamprosate
  • Alcohol Deterrents / adverse effects
  • Alcohol Deterrents / therapeutic use*
  • Alcohol-Related Disorders / drug therapy*
  • Alcohol-Related Disorders / therapy
  • Alcoholism / complications*
  • Alcoholism / drug therapy
  • Alcoholism / psychology*
  • Alcoholism / therapy
  • Depression / complications*
  • Female
  • Humans
  • Male
  • Motivation
  • Patient Compliance
  • Psychiatric Status Rating Scales
  • Substance Withdrawal Syndrome / complications
  • Substance Withdrawal Syndrome / drug therapy
  • Taurine / adverse effects
  • Taurine / analogs & derivatives*
  • Taurine / therapeutic use
  • Temperance
  • Treatment Outcome
  • gamma-Glutamyltransferase / blood


  • Alcohol Deterrents
  • Taurine
  • gamma-Glutamyltransferase
  • Acamprosate