EBV-associated colitis mimicking IBD in an immunocompetent individual

Nat Rev Gastroenterol Hepatol. 2011 Jan;8(1):50-4. doi: 10.1038/nrgastro.2010.192. Epub 2010 Nov 30.


Background: A 30-year-old immunocompetent male with an unremarkable medical history presented with 2 months of lower abdominal bloating and loose, bloody, mucoid bowel movements. He was clinically suspected to have IBD. Due to the progression of his symptoms, he ultimately required hospitalization for further investigation and care.

Investigations: Full medical history and physical examination, routine blood analyses, stool studies, hepatitis serologic tests, abdominal CT, colonoscopy, PCR analysis and light microscopy and immunoperoxidase staining of colonic biopsy samples.

Diagnosis: Epstein-Barr virus (EBV)-associated lymphoproliferative disorder with diffuse colonic involvement (EBV colitis) in an immunocompetent adult.

Management: Inpatient supportive care.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Colitis / diagnosis*
  • Colitis / immunology
  • Colitis / virology*
  • Diagnosis, Differential
  • Endoscopy, Gastrointestinal
  • Herpesvirus 4, Human*
  • Humans
  • Immunocompetence*
  • Inflammatory Bowel Diseases / diagnosis*
  • Male