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Comparative Study
, 104 (1), 175-7

Hand Pattern Indicates Prostate Cancer Risk

Comparative Study

Hand Pattern Indicates Prostate Cancer Risk

A A Rahman et al. Br J Cancer.


Background: The ratio of digit lengths is fixed in utero, and may be a proxy indicator for prenatal testosterone levels.

Methods: We analysed the right-hand pattern and prostate cancer risk in 1524 prostate cancer cases and 3044 population-based controls.

Results: Compared with index finger shorter than ring finger (low 2D : 4D), men with index finger longer than ring finger (high 2D : 4D) showed a negative association, suggesting a protective effect with a 33% risk reduction (odds ratio (OR) 0.67, 95% confidence interval (CI) 0.57-0.80). Risk reduction was even greater (87%) in age group <60 (OR 0.13, 95% CI 0.09-0.21).

Conclusion: Pattern of finger lengths may be a simple marker of prostate cancer risk, with length of 2D greater than 4D suggestive of lower risk.

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    1. Cancer Research UK 2010Prostate Cancer Risks and CausesVol. 2010.London;
    1. Caswell N, Manning JT. A comparison of finger 2D:4D by self-report direct measurement and experimenter measurement from photocopy: methodological issues. Arch Sex Behav. 2009;38:143–148. - PubMed
    1. Gobrogge KL, Breedlove SM, Klump KL. Genetic and environmental influences on 2D:4D finger length ratios: a study of monozygotic and dizygotic male and female twins. Arch Sex Behav. 2008;37:112–118. - PubMed
    1. Jung H, Kim KH, Yoon SJ, Kim TB. 2010Second to fourth digit ratio: a predictor of prostate-specific antigen level and the presence of prostate cancer BJU IntE-pub ahead of print; doi: BJU9490Pii:10.1111/j.1464-410X.2010.09490.x - PubMed
    1. Li H, Stampfer MJ, Giovannucci EL, Morris JS, Willett WC, Gaziano JM, Ma J. A prospective study of plasma selenium levels and prostate cancer risk. J Natl Cancer Inst. 2004;96:696–703. - PubMed

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