How does PKMζ maintain long-term memory?

Nat Rev Neurosci. 2011 Jan;12(1):9-15. doi: 10.1038/nrn2949. Epub 2010 Dec 1.


Most of the molecular mechanisms contributing to long-term memory have been found to consolidate information within a brief time window after learning, but not to maintain information during memory storage. However, with the discovery that synaptic long-term potentiation is maintained by the persistently active protein kinase, protein kinase Mζ (PKMζ), a possible mechanism of memory storage has been identified. Recent research shows how PKMζ might perpetuate information both at synapses and during long-term memory.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Enzyme Activation / physiology
  • Humans
  • Memory, Long-Term / physiology*
  • Protein Kinase C / biosynthesis
  • Protein Kinase C / physiology*
  • Synapses / enzymology


  • Protein Kinase C
  • protein kinase M zeta, rat