Abstract
The first total synthesis of polycyclic Stemona alkaloid maistemonine has been achieved. The efficient approach features a stereoselective intramolecular Schmidt reaction, a ketone-ester condensation, and a Reformatsky reaction. Additionally, another Stemona alkaloid stemonamide was divergently synthesized from a common intermediate.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemical synthesis*
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Alkaloids / chemistry
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Esters / chemistry
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Ketones / chemistry
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Models, Chemical
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Polycyclic Compounds / chemical synthesis*
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Polycyclic Compounds / chemistry
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Spiro Compounds / chemical synthesis*
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Spiro Compounds / chemistry
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Stemonaceae / metabolism*
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Stereoisomerism
Substances
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Alkaloids
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Esters
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Ketones
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Polycyclic Compounds
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Spiro Compounds
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stemonamide