Long term treatment with montelukast and levocetirizine combination in persistent allergic rhinitis: review of recent evidence

J Indian Med Assoc. 2010 Jun;108(6):381-2.


Allergic rhinitis is the most prevalent of the atopic disorders, affecting 25% to 35% of persons, depending on the population studied. Considered by non-sufferers to be a trivial disease, allergic rhinitis delivers a significant personal impact on quality of life. Antihistamines have been successfully used for years in the treatment of seasonal/persistent allergic rhinitis. The new generation antihistaminics are all safe, with negligible sedative effects, excellent tolerability and have no influence on cardiac parameters. Montelukast when used as monotherapy is efficacious and improves quality of life. Combination therapy (montelukast plus levocetirizine) is a more effective strategy than monotherapy in the treatment of persistent allergic rhinitis.

Publication types

  • Review

MeSH terms

  • Acetates / therapeutic use*
  • Cetirizine / therapeutic use*
  • Cyclopropanes
  • Drug Therapy, Combination
  • Histamine H1 Antagonists, Non-Sedating / therapeutic use*
  • Humans
  • Leukotriene Antagonists / therapeutic use*
  • Quality of Life
  • Quinolines / therapeutic use*
  • Randomized Controlled Trials as Topic
  • Rhinitis, Allergic, Perennial / drug therapy*
  • Sulfides


  • Acetates
  • Cyclopropanes
  • Histamine H1 Antagonists, Non-Sedating
  • Leukotriene Antagonists
  • Quinolines
  • Sulfides
  • levocetirizine
  • montelukast
  • Cetirizine