Legionella pneumophila pneumonia in a pregnant woman treated with anti-TNF-α antibodies for Crohn's disease: a case report

J Crohns Colitis. 2010 Dec;4(6):687-9. doi: 10.1016/j.crohns.2010.08.006. Epub 2010 Sep 15.

Abstract

Anti-TNF-α antibodies are widely used. The indications for their usage are still increasing. With their emerging use, their infectious complications are seen more often. We describe the first case of a pneumonia with Legionella pneumophila in a pregnant women with Crohn's disease, during treatment with anti-TNF-α antibodies. She was treated with erythromycin and made a full recovery.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Antibodies, Monoclonal / adverse effects*
  • Crohn Disease / complications*
  • Crohn Disease / drug therapy*
  • Crohn Disease / immunology
  • Erythromycin / therapeutic use
  • Female
  • Humans
  • Immunocompromised Host
  • Immunosuppression Therapy / adverse effects
  • Immunosuppressive Agents / adverse effects*
  • Infliximab
  • Legionella pneumophila / isolation & purification
  • Legionnaires' Disease / complications*
  • Legionnaires' Disease / diagnosis*
  • Legionnaires' Disease / drug therapy
  • Opportunistic Infections / complications*
  • Opportunistic Infections / diagnosis*
  • Opportunistic Infections / drug therapy
  • Pregnancy
  • Pregnancy Complications / drug therapy*
  • Pregnancy Complications / immunology
  • Pregnancy Complications, Infectious / diagnosis*
  • Pregnancy Complications, Infectious / drug therapy
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors

Substances

  • Anti-Bacterial Agents
  • Antibodies, Monoclonal
  • Immunosuppressive Agents
  • Tumor Necrosis Factor-alpha
  • Erythromycin
  • Infliximab