Oral misoprostol as an alternative to surgical management for incomplete abortion in Ghana

Int J Gynaecol Obstet. 2011 Jan;112(1):40-4. doi: 10.1016/j.ijgo.2010.08.022. Epub 2010 Nov 30.


Objective: To investigate whether 600-μg oral misoprostol is an effective alternative to manual vacuum aspiration (MVA) for the treatment of incomplete abortion.

Methods: From June 16, 2004, to July 20, 2005, 230 women of reproductive age presenting with incomplete abortion were randomized in an open-label trial to either 600-μg oral misoprostol or MVA for the treatment of incomplete abortion.

Results: Regardless of the assigned method, more than 98% of participants experienced complete uterine evacuation following initial treatment. Efficacy, acceptability, and satisfaction ratings were similar and high for both methods.

Conclusion: 600-μg oral misoprostol is a safe, effective, and acceptable alternative to MVA for the treatment of incomplete abortion.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abortifacient Agents, Nonsteroidal / administration & dosage
  • Abortifacient Agents, Nonsteroidal / adverse effects
  • Abortifacient Agents, Nonsteroidal / therapeutic use*
  • Abortion, Incomplete / therapy*
  • Adolescent
  • Adult
  • Female
  • Follow-Up Studies
  • Ghana
  • Humans
  • Misoprostol / administration & dosage
  • Misoprostol / adverse effects
  • Misoprostol / therapeutic use*
  • Patient Satisfaction
  • Pregnancy
  • Vacuum Curettage / adverse effects
  • Vacuum Curettage / methods*
  • Young Adult


  • Abortifacient Agents, Nonsteroidal
  • Misoprostol