Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse

Endocr Rev. 2011 Jun;32(3):356-86. doi: 10.1210/er.2010-0009. Epub 2010 Dec 1.


Disruption of the GH receptor (GHR) gene eliminates GH-induced intracellular signaling and, thus, its biological actions. Therefore, the GHR gene disrupted mouse (GHR-/-) has been and is a valuable tool for helping to define various parameters of GH physiology. Since its creation in 1995, this mouse strain has been used by our laboratory and others for numerous studies ranging from growth to aging. Some of the most notable discoveries are their extreme insulin sensitivity in the presence of obesity. Also, the animals have an extended lifespan, which has generated a large number of investigations into the roles of GH and IGF-I in the aging process. This review summarizes the many results derived from the GHR-/- mice. We have attempted to present the findings in the context of current knowledge regarding GH action and, where applicable, to discuss how these mice compare to GH insensitivity syndrome in humans.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Age Factors
  • Animals
  • Female
  • Growth Hormone / physiology
  • Humans
  • Insulin Resistance
  • Insulin-Like Growth Factor I / physiology
  • Male
  • Mice
  • Mice, Knockout
  • Obesity / physiopathology
  • Phenotype
  • Receptors, Somatotropin / deficiency
  • Receptors, Somatotropin / genetics
  • Receptors, Somatotropin / physiology*
  • Signal Transduction


  • Receptors, Somatotropin
  • Insulin-Like Growth Factor I
  • Growth Hormone