[Control of bone remodeling by nervous system. Bone metabolic changes in neurological diseases]

Clin Calcium. 2010 Dec;20(12):1841-9.
[Article in Japanese]


We introduced the relationship between bone change and neurological disturbance in the patients with cerebrovascular disease (CVD) , Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) . High incidence of osteoporosis and right/left difference in osteopenia are found in the diseases. CVD and PD patients with asymmetrical osteopenia show an association between clinical symptoms, peripheral circulatory symptoms, and predominant osteopenia. Although the muscle strength of PD patients was normal, the more severely affected side for PD symptoms and autonomic symptoms coincided with predominant osteopenia in the body. Increased bone resorption was detected in ALS patients. We speculated that neurological disturbances affect the remodeling of local sites of the bone. We have to start treatment from an early stage of the neurological disease to prevent a fracture.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Bone Diseases, Metabolic / etiology*
  • Bone Diseases, Metabolic / metabolism*
  • Bone Remodeling*
  • Bone Resorption / etiology
  • Bone Resorption / metabolism
  • Bone and Bones / metabolism*
  • Cardiovascular Diseases / complications
  • Cardiovascular Diseases / metabolism
  • Fractures, Spontaneous / etiology
  • Fractures, Spontaneous / prevention & control
  • Humans
  • Neurodegenerative Diseases / complications*
  • Neurodegenerative Diseases / metabolism*