Basic science review on adipose tissue for clinicians

Plast Reconstr Surg. 2010 Dec;126(6):1936-1946. doi: 10.1097/PRS.0b013e3181f44790.


The recognition that fat contains stem cells has driven further examination into the potential uses of fat and adipose-derived stem cells in a wide number of clinical situations. New information about the harvesting, isolation, and subsequent differentiation properties of isolated adipose-derived stem cells has led to new research into novel tissue-engineered constructs and the transformation of adipose-derived stem cells to induced pluripotent stem cells. Clinically, use of fat grafts and adipose-derived stem cells worldwide and in the United States has dramatically increased in parallel to questions concerning the safety and efficacy of adipose-derived stem cell-based treatments. Currently, the U.S. Food and Drug Administration has not approved the use of isolated adipose-derived stem cells for medical indications.

Publication types

  • Review

MeSH terms

  • Adipose Tissue / cytology*
  • Adipose Tissue / transplantation*
  • Animals
  • Cell Differentiation / physiology
  • Cell Division / physiology
  • Endothelial Cells / cytology
  • Humans
  • Multipotent Stem Cells / cytology
  • Pluripotent Stem Cells / cytology
  • Stem Cell Transplantation
  • Stem Cells / cytology*
  • Tissue Engineering*
  • Treatment Outcome
  • United States
  • United States Food and Drug Administration