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Review
. 2011 Feb;13(1):42-9.
doi: 10.1007/s11912-010-0144-x.

Incorporation of Biomarker Assessment in Novel Clinical Trial Designs: Personalizing Brain Tumor Treatments

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Free PMC article
Review

Incorporation of Biomarker Assessment in Novel Clinical Trial Designs: Personalizing Brain Tumor Treatments

Evanthia Galanis et al. Curr Oncol Rep. .
Free PMC article

Abstract

Advances in molecular genetics have aided the identification of potential biomarkers with significant clinical promise in neurooncology. These advances and the evolution of targeted therapeutics necessitate the development and incorporation of innovative clinical trial designs that can effectively validate and assess the clinical utility of biomarkers. In this article, we review the use and potential of several such designs in neurooncology trials in order to support the development of personalized treatment approaches for brain tumor patients.

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Fig. 1
Fig. 1
Sample schema for adaptive design

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