Comparison of nimodipine delivery routes in cerebral vasospasm after subarachnoid hemorrhage: an experimental study in rabbits

Acta Neurochir Suppl. 2011;110(Pt 2):23-8. doi: 10.1007/978-3-7091-0356-2_5.

Abstract

Background: nimodipine is the most widely preferred and administered calcium channel blocker in cerebral vasospasm prevention and treatment. There is no experimental or clinical study investigating the comparative effects of routine treatment modalities.

Method: 35 male New Zealand White rabbits were assigned randomly to one of seven groups: Control, only SAH, SAH/oral nimodipine, SAH/IV nimodipine, SAH/IT nimodipine, SAH/IA nimodipine, SAH/angiography.

Findings: basilar artery vessel diameters are measured by angiography. Basilar artery vessel diameters and luminal sectional areas are measured in pathology slides. Basilar artery thicknesses were significantly higher in group 2 and 7 than the others (p < 0.05). Luminal sectional areas in group 5 and 6 were significantly higher than other groups (p < 0.05). We found no significant difference in group 1, 5 and 6 (p > 0.05). Basilar section areas in group 3 and 4 were significantly higher than group 2 but lower than group 1.

Conclusion: this is the first study to show the most effective drug delivery route in CVS after SAH. Nimodipine treatment in cerebral vasospasm is useful. This study showed that selective IA nimodipine treatment and IT nimodipine treatment must be preferred to IV and oral treatments of chronic vasospasm following SAH.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Analysis of Variance
  • Angiography, Digital Subtraction / methods
  • Animals
  • Basilar Artery / diagnostic imaging
  • Basilar Artery / pathology
  • Calcium Channel Blockers / administration & dosage*
  • Disease Models, Animal
  • Drug Delivery Systems / methods*
  • Injections, Intra-Arterial / methods
  • Injections, Intravenous / methods
  • Male
  • Neurologic Examination / methods
  • Nimodipine / administration & dosage*
  • Rabbits
  • Subarachnoid Hemorrhage / complications
  • Vasospasm, Intracranial / diagnostic imaging
  • Vasospasm, Intracranial / etiology
  • Vasospasm, Intracranial / mortality
  • Vasospasm, Intracranial / prevention & control*

Substances

  • Calcium Channel Blockers
  • Nimodipine