B7-h3 and its role in antitumor immunity

Clin Dev Immunol. 2010;2010:683875. doi: 10.1155/2010/683875. Epub 2010 Nov 28.

Abstract

B7-H3 is one of the most recently identified members of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T-cell response. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity. However, its precise physiologic role is still elusive, because both stimulatory and inhibitory capacities have been demonstrated. This paper summarizes the available data on B7-H3 in the regulation of T-cell response focusing on its potential role in antitumor immunity.

Publication types

  • Review

MeSH terms

  • Antigens, CD* / immunology
  • Antigens, CD* / therapeutic use
  • B7 Antigens
  • Biomarkers, Tumor* / immunology
  • Biomarkers, Tumor* / therapeutic use
  • Cytokines / biosynthesis
  • Cytokines / immunology*
  • Female
  • Humans
  • Immunomodulation
  • Lymphocyte Activation / immunology*
  • Lymphocytes, Tumor-Infiltrating / immunology
  • Lymphocytes, Tumor-Infiltrating / metabolism
  • Male
  • Neoplasms / immunology*
  • Neoplasms / physiopathology
  • Neoplasms / therapy
  • Receptors, Immunologic / genetics*
  • Receptors, Immunologic / immunology
  • Receptors, Immunologic / metabolism
  • Receptors, Immunologic / therapeutic use
  • Survival Analysis
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / metabolism

Substances

  • Antigens, CD
  • B7 Antigens
  • Biomarkers, Tumor
  • CD276 protein, human
  • Cytokines
  • Receptors, Immunologic