An update on etiology, prevention, and therapy of postthrombotic syndrome

J Vasc Surg. 2011 Feb;53(2):500-9. doi: 10.1016/j.jvs.2010.08.050. Epub 2010 Dec 3.


Postthrombotic syndrome is a common sequelae resulting from deep venous thrombosis. The primary interventions are prevention and treatment, both of which many vascular specialists may not always recognize. We review the definition, epidemiology, the basic pathophysiology, and preventative management for postthrombotic syndrome. The current primary medical and interventional treatment modalities to decrease the occurrence of postthrombotic syndrome are also highlighted. Many of these treatments are currently available and simply need to be adhered to, whereas others are a shift in the paradigm, focusing on active thrombus removal.

Publication types

  • Review

MeSH terms

  • Animals
  • Anticoagulants / therapeutic use
  • Fibrinolytic Agents / therapeutic use
  • Humans
  • Postthrombotic Syndrome* / etiology
  • Postthrombotic Syndrome* / prevention & control
  • Postthrombotic Syndrome* / therapy
  • Preventive Health Services
  • Recurrence
  • Risk Factors
  • Terminology as Topic
  • Thrombectomy
  • Thrombolytic Therapy
  • Treatment Outcome
  • Venous Thrombosis* / complications
  • Venous Thrombosis* / prevention & control
  • Venous Thrombosis* / therapy


  • Anticoagulants
  • Fibrinolytic Agents