SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model

FEBS Lett. 2011 Apr 6;585(7):986-94. doi: 10.1016/j.febslet.2010.11.047. Epub 2010 Dec 2.


Ageing in mammals remains an unsolved mystery. Anti-ageing is a recurring topic in the history of scientific research. Lifespan extension evoked by Sir2 protein in lower organisms has attracted a large amount of interests in the last decade. This review summarizes recent evidence supporting the role of a Sir2 mammalian homologue, SIRT1 (Silent information regulator T1), in regulating ageing and cellular senescence. The various signaling networks responsible for the anti-ageing and anti-senescence activity of SIRT1 have been discussed. In particular, a counter-balancing model involving the cross-talks between SIRT1 and AMP-activated protein kinase (AMPK), another stress and energy sensor, is suggested for controlling the senescence program in mammalian cells.

Publication types

  • Review

MeSH terms

  • AMP-Activated Protein Kinases / metabolism*
  • Animals
  • Cellular Senescence*
  • Humans
  • Models, Biological*
  • Receptor Cross-Talk
  • Signal Transduction
  • Sirtuin 1 / metabolism*


  • AMP-Activated Protein Kinases
  • Sirtuin 1