Will newer tyrosine kinase inhibitors have an impact in AML?

Best Pract Res Clin Haematol. 2010 Dec;23(4):489-94. doi: 10.1016/j.beha.2010.09.008. Epub 2010 Nov 5.

Abstract

FLT3 inhibition has been a goal of acute myeloid leukemia (AML) therapy since FLT3 mutations were discovered to have a role in AML. Several FLT3 inhibitors have been developed in the last several years, beginning with less potent, less selective agents. The newer FLT3 inhibitors appear to be more potent in vivo and have shown more promise than the older agents in monotherapy trials.

Publication types

  • Review

MeSH terms

  • Clinical Trials as Topic
  • Humans
  • Leukemia, Myeloid, Acute* / drug therapy
  • Leukemia, Myeloid, Acute* / enzymology
  • Leukemia, Myeloid, Acute* / genetics
  • Mutation*
  • Protein Kinase Inhibitors / therapeutic use*
  • fms-Like Tyrosine Kinase 3 / antagonists & inhibitors*
  • fms-Like Tyrosine Kinase 3 / genetics*

Substances

  • Protein Kinase Inhibitors
  • FLT3 protein, human
  • fms-Like Tyrosine Kinase 3