Characterizing sleep disorders of adults with tuberous sclerosis complex: a questionnaire-based study and review

Epilepsy Behav. 2011 Jan;20(1):68-74. doi: 10.1016/j.yebeh.2010.10.023. Epub 2010 Dec 3.


An adult cohort with tuberous sclerosis complex was investigated for the prevalence of sleep disturbances and the relationship with seizure variables, medication, and psychological functioning. Information on 35 adults was gathered using four questionnaires: Epworth Sleepiness Scale (ESS), Sleep and Epilepsy Questionnaire (SEQ), Sleep Diagnosis List (SDL), and Adult Self-Report Scale (ASR). In addition, clinical, genetic and electrophysiological data were collected. Of 35 respondents, 25 had a history of epilepsy. A subjective sleep disorder was found in 31% of the cohort. Insomnia scores showed a significant positive correlation with obstructive sleep apnea syndrome and restless legs syndrome scores. Significant correlations were found between daytime sleepiness and scores on depression, antisocial behavior, and use of mental health medication. A subgroup using antiepileptic medication showed high correlations between daytime sleepiness, attention deficits, and anxiety scores.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • DNA Mutational Analysis
  • Electroencephalography
  • Female
  • Humans
  • Male
  • Sleep Wake Disorders / complications*
  • Sleep Wake Disorders / diagnosis*
  • Sleep Wake Disorders / genetics
  • Surveys and Questionnaires
  • Tuberous Sclerosis / complications*
  • Tuberous Sclerosis / genetics