Signaling of interleukin-17 family cytokines in immunity and inflammation

Cell Signal. 2011 Jul;23(7):1069-75. doi: 10.1016/j.cellsig.2010.11.022. Epub 2010 Dec 2.


IL-17 cytokine family, though still young since discovery, has recently emerged as critical players in immunity and inflammatory diseases. The prototype cytokine, IL-17A, plays essential roles in promoting inflammation and host defense. IL-17RA, a member of the IL-17 receptor family, forms a complex with another member, IL-17RC, to mediate effective signaling for IL-17A as well as IL-17F, which is most similar to IL-17A, via Act1 and TRAF6 factors. On the other hand, IL-17RA appears to interact with IL-17RB to regulate signaling by another cytokine IL-25. IL-25, the most distant from IL-17A in the IL-17 family, is involved in allergic disease and defense against helminthic parasites. In this review, we discuss recent advancements on signaling mechanisms and biological functions of IL-17A, IL-17F and IL-25, which will shed light on the remaining IL-17 family cytokines and help understand and treat inflammatory diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Bone Marrow Cells / immunology
  • Bone Marrow Cells / metabolism
  • Humans
  • Immunity*
  • Inflammation / immunology
  • Inflammation / metabolism*
  • Interleukin-17 / immunology
  • Interleukin-17 / metabolism*
  • Mitogen-Activated Protein Kinases / metabolism
  • NF-kappa B / metabolism
  • Protein Structure, Tertiary
  • Receptors, Interleukin / metabolism
  • Signal Transduction*
  • TNF Receptor-Associated Factor 6 / metabolism
  • Transcription Factors / metabolism
  • Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / metabolism


  • Adaptor Proteins, Signal Transducing
  • Interleukin-17
  • NF-kappa B
  • Receptors, Interleukin
  • TNF Receptor-Associated Factor 6
  • TRAF3IP2 protein, human
  • Transcription Factors
  • Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
  • Mitogen-Activated Protein Kinases