Abstract
The Krox-20 gene is rapidly and transiently induced when quiescent 3T3 cells are stimulated to reenter the proliferative cycle. We identified the major serum-responsive transcription initiation site and found that it differs from the initiation sites previously identified for the Krox-20 gene. Transcripts from the major serum-responsive initiation site increased at least 40-fold in serum-stimulated cells compared with logarithmically growing cells.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Base Sequence
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Blood
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Cells, Cultured
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Culture Media
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Cycloheximide / pharmacology
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DNA-Binding Proteins / genetics*
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Early Growth Response Protein 2
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Gene Expression Regulation*
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Genes
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Kinetics
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Metalloproteins / genetics*
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Mice
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Molecular Sequence Data
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Nucleotide Mapping
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RNA, Messenger / genetics
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Sequence Homology, Nucleic Acid
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Transcription Factors / genetics*
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Transcription, Genetic* / drug effects
Substances
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Culture Media
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DNA-Binding Proteins
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Early Growth Response Protein 2
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Egr2 protein, mouse
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Metalloproteins
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RNA, Messenger
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Transcription Factors
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Cycloheximide