Clinical inquiries. Do intra-articular steroid injections affect glycemic control in patients with diabetes?

J Fam Pract. 2010 Dec;59(12):709-10.


Yes, but the clinical importance is minimal. A single intra-articular steroid injection into the knee produces acute hyperglycemia for 2 or 3 days in patients with diabetes who otherwise have good glucose control (strength of recommendation [SOR]: B, small cohort studies). Intra-articular steroid injections into the shoulder may briefly raise postprandial (but not mean) glucose levels with larger and repeated doses (SOR: C, extrapolated from heterogeneous and mixed cohort studies).

Publication types

  • Review

MeSH terms

  • Blood Glucose / drug effects*
  • Diabetes Mellitus / blood*
  • Glucocorticoids / administration & dosage*
  • Glucocorticoids / adverse effects*
  • Humans
  • Injections, Intra-Articular
  • Osteoarthritis / blood
  • Osteoarthritis / complications
  • Osteoarthritis / drug therapy*


  • Blood Glucose
  • Glucocorticoids