Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression

Kadri Andre; Olli Kampman; Eija Setälä-Soikkeli; Merja Viikki; Outi Poutanen; Timo Nuolivirta; Nina Mononen; Terho Lehtimäki; Esa Leinonen; Ari Illi

doi:10.1007/s00702-010-0512-6

Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression

J Neural Transm (Vienna). 2010 Dec;117(12):1431-4. doi: 10.1007/s00702-010-0512-6. Epub 2010 Dec 7.

Authors

Kadri Andre¹, Olli Kampman, Eija Setälä-Soikkeli, Merja Viikki, Outi Poutanen, Timo Nuolivirta, Nina Mononen, Terho Lehtimäki, Esa Leinonen, Ari Illi

Affiliation

¹ Medical School, University of Tampere, 33014 Tampere, Finland. kadriandre@hot.ee

PMID: 21136126
DOI: 10.1007/s00702-010-0512-6

Abstract

Variation in antidepressive medication response according to 5-HT2A genotype has been reported in several studies. Temperament has been proposed to be one of the vulnerability factors in mood and anxiety disorders. We studied temperament profiles of 98 patients with major depression and explored the interaction between Temperament and Character Inventory (TCI) temperament dimensions, 5-HT2A genotype (SNPs rs6311, rs6313 and rs7997012) and treatment response. No interactive effects for TCI temperament dimensions and 5-HT2A genotypes on antidepressive treatment response were found.

MeSH terms

Adult
Aged
Depressive Disorder, Major / drug therapy*
Depressive Disorder, Major / genetics*
Depressive Disorder, Major / psychology
Drug Resistance / genetics*
Female
Humans
Male
Middle Aged
Receptor, Serotonin, 5-HT2A / genetics*
Selective Serotonin Reuptake Inhibitors / pharmacology*
Temperament / drug effects
Temperament / physiology*
Young Adult

Substances

Receptor, Serotonin, 5-HT2A
Serotonin Uptake Inhibitors