Diagnosis and treatment of Acanthosis nigricans

Skinmed. 2010 May-Jun;8(3):161-4; quiz 165.

Abstract

Acanthosis nigricans is a dermatologic condition commonly seen in diabetics and obese individuals. Histologically, it is characterized by the proliferation of epidermal keratinocytes and fibroblasts. Clinically, the lesions appear as dark-brown thickened plaques. The neck and the axillas are the most commonly affected sites. Treatment involves management of the underlying disorder. Topical tretinoin and calcipotriol have also been used with some limited success. Other treatment options include laser and surgical excision.

Publication types

  • Review

MeSH terms

  • Acanthosis Nigricans / diagnosis
  • Acanthosis Nigricans / etiology
  • Acanthosis Nigricans / therapy*
  • Administration, Cutaneous
  • Axilla
  • Calcitriol / administration & dosage
  • Calcitriol / analogs & derivatives
  • Calcitriol / therapeutic use
  • Dermatologic Agents / administration & dosage
  • Dermatologic Agents / therapeutic use
  • Diabetes Mellitus / physiopathology*
  • Fibroblasts / metabolism
  • Humans
  • Keratinocytes / metabolism
  • Neck
  • Obesity / complications*
  • Tretinoin / administration & dosage
  • Tretinoin / therapeutic use

Substances

  • Dermatologic Agents
  • calcipotriene
  • Tretinoin
  • Calcitriol