Targeting BRAF for patients with melanoma

Br J Cancer. 2011 Feb 1;104(3):392-8. doi: 10.1038/sj.bjc.6606030. Epub 2010 Dec 7.


The prognosis of patients with metastatic melanoma is poor and not influenced by systemic therapy with cytotoxic drugs. New targeted agents directed against the RAS-RAF-MEK-ERK pathway show promising activity in early clinical development and particular interest is focused on selective inhibitors of mutant BRAF, which is present in one half of the cases of metastatic melanoma. The majority of patients on early trials of these drugs develop secondary resistance and subsequent disease progression and it is, therefore, critical to understand the underlying escape mechanisms leading to resistance.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Drug Resistance, Neoplasm*
  • Humans
  • Melanoma / genetics
  • Melanoma / secondary
  • Melanoma / therapy*
  • Mutation
  • Prognosis
  • Protein Kinase Inhibitors / therapeutic use
  • Proto-Oncogene Proteins B-raf / antagonists & inhibitors*
  • Proto-Oncogene Proteins B-raf / genetics*
  • Skin Neoplasms / genetics
  • Skin Neoplasms / pathology
  • Skin Neoplasms / therapy*


  • Antineoplastic Agents
  • Protein Kinase Inhibitors
  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf