C-reactive protein levels are elevated in asthma and asthma-like conditions

Clin Lab Sci. Fall 2010;23(4):223-7.

Abstract

Objective: Asthma is a chronic disease involving airway hyperresponsiveness. It was proposed that asthma/chronic shortness of breath elicit chronic systemic inflammation even in the absence of episodic events.

Design: Volunteers completed questionnaires relevant to asthma and/or dyspnea and consented to C-reactive protein (CRP) quantitation. Subject groups were: control (no reported dyspnea) and asthma/shortness of breath [dyspnea] group.

Setting: Studies were performed in the Saint Louis metropolitan area.

Participants: Participants consisted of volunteers aged 18-57. Inclusion criteria were good health, not pregnant, weight > 110 pounds and absence of antiinflammatory medicine use.

Results: Serum CRP ranged from undetectable to 22,013 ng/mL. Mean results for asthmatic/dyspnea (n = 22) and control (n = 27) groups were 4,203 +/- 1,323 ng/mL and 1,741 +/- 467 ng/mL (p < 0.05) respectively.

Conclusion: Individuals with asthma/asthma-like symptoms have chronic low levels of systemic inflammation despite the absence of episodic pulmonary events. Understanding chronic systemic inflammation relevant to asthma/asthma-like conditions may lead to design of targeted therapeutics.

MeSH terms

  • Adolescent
  • Adult
  • Asthma / blood*
  • Asthma / pathology
  • C-Reactive Protein / metabolism*
  • Dyspnea / blood
  • Female
  • Humans
  • Male
  • Middle Aged
  • Surveys and Questionnaires
  • Young Adult

Substances

  • C-Reactive Protein