Sugar-sweetened beverages and hypertension

Future Cardiol. 2010 Nov;6(6):773-6. doi: 10.2217/fca.10.92.


Consumption of sugar-sweetened beverages has been associated with the development and maintenance of obesity, as well as the risk for multiple obesity-related comorbidities. Some experts have hypothesized that the effect is entirely associated with excess caloric intake, while others suggest that a component of sweeteners may have a physiologic impact on the development of hypertension, insulin resistance and nonalcoholic fatty liver disease. Chen et al. have presented the first, large-scale clinical trial, assessing the direct effect of modest changes in sweetened drink consumption on blood pressure in a racially diverse population. The study team utilized data from the PREMIER: Lifestyle Interventions for Blood Pressure Control trial, in which 810 adult subjects were randomized to three groups: advice only; comprehensive lifestyle modification aimed at weight loss, increased exercise and dietary sodium reduction; or comprehensive lifestyle modification with incorporation of the Dietary Approach to Stop Hypertension (DASH) diet. Sweetened drink intake was estimated from 24-h subject recall, assessed by unscheduled phone calls to subjects at baseline, 6 months and 18 months. Over the duration of the study, a reduction of one 12-oz serving of sugar-sweetened beverages per day was associated with an average of 1.8 mmHg reduction in systolic blood pressure and an average of 1.1 mmHg reduction in diastolic blood pressure.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Beverages*
  • Blood Pressure*
  • Dietary Sucrose / therapeutic use*
  • Humans
  • Hypertension / diet therapy
  • Hypertension / etiology*
  • Hypertension / prevention & control
  • Life Style
  • Mental Recall
  • Multivariate Analysis
  • Randomized Controlled Trials as Topic
  • Regression Analysis
  • Statistics, Nonparametric
  • United States


  • Dietary Sucrose